Non-Invasive Prenatal Genetic Screening to Detect Trisomies In Singleton and Twin Pregnancies

Background Screening for fetal anomalies is one of the most critical parts prenatal testing to reduce burden chromosomal aberrations and improve clinical outcomes in pregnancy. The available literature suggests that India carries a strong economic, emotional, health care new-born genetic diseases. Material Methods: We present single-center retrospective study 200 singletons 6 dichorionic diamniotic twin gestations screened abnormalities trisomies using NIPT. patients were presented with gestation period 10-12 (plus few days) weeks, clinically confirmed singleton or dizygotic twins, who underwent NIPT between years 2021-2022 (mid) at our center. All sonographic examination biochemical investigations regular follow-up counseling. history family presence any disease other previously taken by clinician all cases. main indications increased risk found markers test, advanced maternal age, some mild complications Results; Out total (206) pregnancies, only 2 cases high screen, prospectively followed up, showed normal twins six pregnancy growing successfully. high-risk genetically counselled further tests amniotic chorionic villi samples recommended follow-up. Conclusion: This clearly indicates non-invasive safe effective screening test rule out certain omit need invasive among low-risk